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"Grey's Anatomy" Season Four Promos

Grey’s Anatomy Season 4 promos have arrived!

Pictured: Ellen Pompeo as Meredith Grey, Patrick Dempsey as Derek Shepherd, Sandra Oh as Cristina Yang, Katherine Heigl as Isobel “Izzie” Stevens, T.R. Knight as George O’Malley, Justin Chambers as Alex Karev, Chandra Wilson as Miranda Bailey, James Pickens, Jr. as Richard Webber, Sara Ramirez as Callie Torres, Eric Dane as Mark Sloan and newcomer Chyler Leigh as Lexie Grey.

The season 4 premiere episode “A Change is Gonna Come” of Grey’s Anatomy airs on Thursday, Sept. 27 @ 9PM ET/PT on ABC.

20+ promos inside of season 4 of Grey’s Anatomy

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  • Francesca

    i can’t wait till greys season 4 i no it wont b the same but i am going to follow grey’s until the end. i can’t believe isaiah and kate are both gone. sandra oh / christina looks different cool but sad and weathered and wiser than before. to bad about her and burke. they really all do look kind of sad. and lexie doesn’t need to be in the pics yet she hasn’t really earned it. ever want to talk greys go to my site it really sux but plz sign guest book. or email me at

  • Lemoin

    Anyone think that they sorta are… identicle to the Season 4 OC promo shots. It’s exact copy.

  • kath

    they are such a HOT cast!!!!

  • nigella

    Pretty sure the solo pics of Sara Ramirez/Callie aren’t new, and I don’t believe Patrick’s are either, so where the hell are their new ones?!?!

    Gotta say though, Sara steals the spotlight, that woman just gets better and better looking!

  • angie

    agree with kath. they are a hot cast. mcdreamy looks SO much better with short hair. katherine looks gorgeous as usual. i dont really like ellen but i guess her hair is an improvement…im interested in this season. how are they going to go with it without burke or addison? anyhow, i’ll be watching this show! interestingly enough, i dont dislike lexie! i think she’ll be a refreshing character to see on the show. she’s also very pretty.

  • xy

    Justin looks so HOT

  • ****

    Now with 100% less Isaiah Washington promo shots! Yezzir!

  • Calliope

    Grey’s cast is beautiful without McWhore Walsh.
    Her show will be a flop but her new husband will help her fake career.

  • Aga

    Where is Preston Burke???????

  • benitodelicias

    why on earth is Eric Dane still on this show? He gets nothing to do…he’s just eye candy that’s it….

    there are some serious hair problems for TR Knight and Chandra Wilson….

  • washington

    I miss burke, they are a bunch of real morons for letting him go

  • curious

    I always get angry when i read fans comment. Some people can be malicious, spiteful, vindictive and plain rude. The only explaination i can come with is; either jeolousy or joblessness. Firstly, Seriously, you guys think ellen pompeo is ugly? really? how on earth can you look at that woman and think she is ugly? how? Lets face it, its either you like an actress or you dont and that is not a crime, but dont call her ugly out of spite. Yeah everyone is beautiful in a certain way some obvious and some not. Secondly, why is her boyfriend always an issue here? the woman is grateful she has a job and she is trying her possible best. Again yeah some actresses are more talented than others, but that doesnt mean is cant act. All i am saying is everyone has his/her fav characters, i have mine, but i dont go making nasty comments on them. You people should grow up.

  • #55 is right on

    #55 Were you reading my mind? I hate Meredith’s whiny personality (not EP b/c I don’t know her) And TR’s character has to change his “ticks” it drives me crazy….I want to itch every time he acts in a scene.

  • Violet

    curious I agree with you

  • robyn

    I wish Grey’s alot of luck this year. I dont know why Ms. Shondra decided it was necessary to add a sister of meredith;s to the cast. And don’t tell me that this is her baby and she can do whatever she pleases that is a given. As if we don’t have enough brunettes and blondes on the show. I started watching Grey’s because of Justin Chambers and in the process happen to fall in like with Isiah Washington and Sandra’s characters. Ms Wilson is just a joy to watch. I don’t give a crap about George or Izzie’s characters they are pathetic. Callie’s character is pretty awesome. I really hope she adds more Latin and Black Americans to the cast because a little ethnicity never hurt anyone.

  • Katie

    I’m surprised that the promo pics show George in his scrubs & white coat – I thought he was quitting because he failed his test?

    Anyways, I’m jonesing hard for Grey’s to start again. I lovelovelove Sara Ramirez. I’ll miss Addison though!

  • Twisted

    You know you people are so judgemental its ridiculous. Besides not unless you have seen the first couple of episodes already you cant be jumping on Lexie’s case. I think she deserves to be in this promo just as much as anyone else does. She’s going to be a cast regular get over it. This season i heard is going to be way lighter than last season. Just give it a freakin chance damn!

  • Maike

    hey i`m from germany and i´ve got a question.where is addison?because the 3rd season is not finished here,,and i really hoped that she and alex would come together :(

  • Maike

    where is addison?i am from germany and the 3rd season is not finished here….and i really hoped that she and alex would come togehter

  • miriam

    estoy muy enojada porque al parecer en la cuarta temporada de anatomia de grey derek va a tener alguna relación con la tonta hermanastra de meredith lexi que yo no se ni que tiene que hacer ahi, no es justo derek y meredith ya se merecen su final feliz o al menos ya un buen rato de felicidad sin que otras viejas se metan en medio.