Patrick Dempsey & Michelle Monaghan - MTV's TRL

Patrick Dempsey and Michelle Monaghan visit MTV’s TRL in Times Square on Monday in New York City.

Dempsey and Monaghan‘s Made of Honor hits theaters this Friday May 2nd.

The Grey’s Anatomy star, 42, plays a man named Tom Bailey who is in love with his best friend, Hannah. After a rich Scotsman sweeps her off her feet, things get interesting when Hannah asks Tom to be her Maid of Honor!

Patrick will be accompanied by none other than Donatella Versace at the Rome premiere. He currently serves at the face of Versace, for the 2008 spring/summer line.

10+ pictures of Patrick Dempsey and Michelle Monaghan at MTV’s TRL…