According to TMZ, the 49-year-old rocker, whose real name is Saul Hudson, filed the papers on Tuesday (December 30) in Los Angeles.
He cited “irreconcilable differences” as reason for the split. The couple, who married in 2001, has two sons together and he’s seeking joint custody.
Slash also filed divorce papers back in 2010, but withdrew them after they worked things out.
Perla reportedly gave him an ultimatum that expired on New Year’s Day.