Reese Witherspoon is a 'Newly Separated Loser' in 'Home Again' Trailer - Watch Now! (Video)

Reese Witherspoon is starting over again in the new trailer for her upcoming rom-com Home Again!

In the film, the 41-year-old actress plays newly single mom Alice.

According to Deadline, “Following her separation, Alice decides to start over by moving back to her hometown of Los Angeles with her two young daughters as well as three aspiring filmmakers. Her unlikely new family and new romance comes to a crashing halt when her ex-husband shows up, suitcase in hand.”

Home Again, directed by first-time filmmaker Hallie Meyers-Shyer, is set to hit theaters on September 8.

It also stars Pico Alexander, Nat Wolff, Jon Rudnitsky, Michael Sheen, Candice Bergen, and Lake Bell.

Watch the trailer below!