Rose Byrne Got To Tell Oprah Winfrey To 'Shut The F**k Up'!

Rose Byrne stars alongside Oprah Winfrey in their brand new HBO film The Immortal Life of Henrietta Lacks – and she didn’t hold back!

In one scene, the 37-year-old actress, who plays journalist Rebecca Skloot, had to yell at Oprah‘s character (Deborah Lacks) to “shut the f**k up.”

“It was intense! It was a long day, but we wanted to do a good job and we were g-ed up to do it,” Rose expressed at the premiere. “It was one of those strange surreal moments in your life but that’s acting you know? I think I said that to Glenn Close a few times as well so I’m clearly cornering a market, telling legendary woman to eff off.”

Pictured: Rose striking a pose outside of the Ed Sullivan Theater before making an appearance on The Late Show with Stephen Colbert on Wednesday (April 19) in New York City.

FYI: Rose is wearing a Zimmerman top and skirt, Jimmy Choo shoes and Broken English Jewelry.